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PHYSIOLOGICAL RESEARCH, Volume 73, pages 515-527

When Raufman met Pisano, they hit it off, not least because Raufman had hoped to find something meaty and interesting to investigate

In the STEP UP clinical trial, the 7.2 mg dose produced a mean weight loss of 20.7% at 72 weeks, compared with 17.5% at the previously approved 2.4 mg dose and 2.4% with placebo

Moreover, shifts in the cellular glutathione redox state may reversibly modify redox-sensitive thiol groups in target proteins, either through glutathionylation or formation of cysteine cross bridges

The Hageman factor and complement and kinin systems are activated, which leads to collagen degradation and increases the permeability of cutaneous vessels (162)