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Conversely, GA, CGA, and Q3G increased antiinflammatory cytokines, such as IL-10, IL-4, and IL-5 [20, 23, 33], indicating a balanced modulation of the inflammatory response

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The authors argue that the senescence-induced suppression of Klotho turns a local renal problem into a systemic catastrophe, accelerating vascular calcification, cognitive decline, and sarcopenia