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Abstract The activation of pancreatic stellate cells (PSCs) is the key mechanism of pancreatic fibrosis, which can lead to -cell failure

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L-cells are nutrient sensitive and GLP-1 is secreted in response to glucose ( Reference Reimann, Habib and Tolhurst 21 ) , proteins ( Reference Hall, Millward and Long 22 , Reference Power, Conway and McCormack 23 ) peptides ( Reference Hira, Mochida and Miyashita 24 ) , amino acids ( Reference Oya, Kitaguchi and Pais 25 , Reference Reimann, Williams and Silva Xavier 26 ) and lipids ( Reference Lindgren, Carr and Deacon 27 )