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Although approximately 1 in 1500 patients exhibit signs of chronic liver injury in long-term prophylactic therapy, acute liver injury due to NFT is quite rare, with approximately 0.3 cases per 100,000 prescriptions (LiverTox 2020)

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doi:10.1093/ajcn/32.1.258.[Crossref], [PubMed], [Web of Science ] , [Google Scholar]) found that germ-free Guinea pigs drinking water with 5% PGN exhibited a lack of colonic inflammation, though the exposure was only for 14 days, while the normal Guinea pigs developed typical lesions after PGN dosed the same way

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