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Peak sales predictions for the combination are approximately $5 billion by 2032
The gradual increase helps reduce risks and improve tolerance
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However, a low-calorie diet along with GLP-1 agonist drugs can also lead to loss of lean mass, emphasizing the need for protein intake with resistance training to preserve muscle mass
-diversity analysis revealed no significant differences in Shannon and Simpson indices of gut microbiota among groups (Figure 2B), suggesting that berberine intervention did not significantly alter the richness or overall diversity of gut microbiota
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