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When weight loss reaches a significant level, muscle mass and bone integrity tend to diminish as well
In the Phase 2 trial at 48 weeks (NEJM 2023): Every single participant on 12 mg lost at least 5% of their body weight
The activation of focal adhesion signaling through phosphorylation of FAK and paxillin is also posited to assist cell attachment and movement within the extracellular matrix and thereby facilitate repair
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