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The dual and triple receptor agonist formulations are also expected to undergo cardiovascular outcomes trials
44 The 52-week data from 966 patients with MASH and F1B, F2, or F3 fibrosis in the MAESTRO-NASH trial revealed significant effects of resmetirom on MASH resolution, fibrosis improvement, and LDL cholesterol reduction (NCT03900429), 77 forming the basis for potential FDA approval of resmetirom for MASH treatment
These are two incretin hormones that affect our metabolism and appetite
Clinical data shows that adding GIP agonism produces an additional 3-5% weight loss compared to GLP-1/GIP dual therapy alone
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