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Side effect comparison: Nausea: Similar rates between the two compounds Vomiting: Cagrilintide significantly lower (OR 0.38) Diarrhea: Comparable rates Constipation: Similar Injection site reactions: Cagrilintide substantially higher Discontinuation due to AEs: Cagrilintide much lower (1% vs approximately 5-7%) The takeaway: if vomiting was your main problem on semaglutide, cagrilintide may be worth exploring
But with a 2mg/mL concentration (5mL of water added), that same 4mg dose requires 2.0mL of liquid, which is an entire insulin syringe worth and creates a large, uncomfortable injection volume
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The MS conditions used for Q-TOF were as follows: nebulizer, 1.0 bar
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