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Behav Pharmacol
Wegovy is also approved to help treat MASH and to help lower the risk of serious heart problems like heart attack and stroke in adults with cardiovascular disease and either obesity or overweight
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
Typical titration schedule in trials: Start at 2 mg weekly Increase every 4 weeks: 2 mg 4 mg 6 mg 9 mg or 12 mg (depending on target dose) This means it takes 3-4 months to reach the maximum dose Meaningful weight loss becomes apparent after reaching therapeutic doses and maintaining them for several weeks
A controlled study (PMID: 7777652) found that DSIP did not significantly affect CRH- or meal-induced ACTH and cortisol secretionindicating DSIP does not measurably blunt the human cortisol response, contrary to stress-protective effects suggested by some animal studies
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