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Diabetes is a complex metabolic disorder characterized by hyperglycemia that occurs from defects in insulin secretion, insulin action, or both
46 High intratumoral expression of CYP3A4 can accelerate the metabolic inactivation of chemotherapeutic agents such as paclitaxel and docetaxel, thereby reducing local drug bioavailability, diminishing therapeutic efficacy, and ultimately contributing to drug resistance
This is when the medication starts to have a more noticeable impact on appetite and food intake, particularly when combined with lifestyle changes like improved diet and regular exercise
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