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The precise mechanism of action of semaglutide in AD remains to be fully elucidated
Regarding possible mechanisms, the researchers explained that the 5:2 MR may reshape the gut microbiota, promote white adipose tissue browning, and consequently reduce insulin resistance and the occurrence of obesity. They added that the meal replacement product used in the study contained omega-3 fatty acids and medium-chain fatty acids, which produce fat breakdown and reduce heterotopic fat, respectively
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Although the peptide is reported to be stable in gastric juice, its bioavailability may be lower with this route
