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Ann Neurol 39:147157 Desnuelle C, Dib M, Garrel C, Favier A (2001) A double-blind, placeho-controlled randomized clinical trial of -tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis

This dual mechanism is the pharmacological reason tirzepatide produces greater average weight loss than GLP-1 single-agonists in clinical trial data

Assuming this reflects circulating corticosterone, this could stimulate appetite and fat deposition while decreasing thermogenesis and metabolic rate 36

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These pathogenic mechanisms have direct clinical consequences and inform targeted therapeutic strategies