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Its Phase 2/3 LIFT-AD Alzheimer's trial failed its primary endpoint in September 2024 (GST 0.08, P=.70)

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Embedded in the basement membrane (BM), they are distinguished by their protruding ovoid cell bodies and elongated, slender processes that partly form an incomplete layer over the surface of CNS capillaries [40, 41]

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Experimental investigations suggest that modulation of NNMT activity may influence cellular pathways associated with energy utilization, nutrient partitioning, and metabolic adaptation

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