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Two investigators (HW and TG) independently performed the data extraction from each publication using a standardized form: publication data, baseline characteristics of the study population (sample size, sex, age, body mass index (BMI), body weight, abdominal circumference, waist-to-hip ratio, visceral adipose tissue (measured by computed tomography, magnetic resonance imaging, or dual-emission X-ray absorptiometry)), duration of follow-up, weight change during treatment and after treatment discontinuation, description of the weight management group and control group

Tirzepatide pros Effective for weight loss : Tirzepatide has shown significant weight loss results, with some patients losing over 20% of their body weight, especially in people with obesity

doi:10.1016/j.cmet.2012.10.007

90% of the 38 million type 2 diabetics in the US are overweight

The risk of hypoglycaemia is low with semaglutide alone but increases when used with insulin or sulfonylureas