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Nausea is a common side effect of Tirzepatide, but it often improves after adjusting the dose

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However, if any severe symptoms are experienced, such as significant upper abdominal pain with nausea and vomiting, we recommend urgent evaluation given the possibility of pancreatitis or other more acute conditions

Sources: 5 PubMed-indexed papers linked below

Those in the higher arms were begun at a lower amount and stepped up at four-week intervals until they reached their assigned arm, and the protocol deliberately tested two different starting amounts within the 4 mg and 8 mg arms to compare how escalation pace affected tolerability