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Among these infiltrating cells, macrophages in synovial tissue, as an early cell subpopulation to enter the joint and synovial area, are the main contributors of tumor necrosis factor (TNF), profoundly mediating the chronic development of RA [49]
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The requirement for cationic CPP in our study is consistent with findings from other studies, where CPPs with hydrophobic motifs did not significantly enhance cell uptake 60
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