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The cardiovascular safety of this dose of semaglutide is currently being evaluated in the SELECT trial, where 17,500 individuals with obesity and established CVD are randomised to semaglutide or placebo for 2.5-5 years
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Wu Z, et al
A constant lack of sleep and ongoing stress can cause spikes in cortisol levels
They are already experiencing age-related muscle loss (sarcopenia) at a rate of 1 to 2% per year, and adding semaglutide-induced weight loss on top accelerates the problem
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