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A 2026 narrative review covering six studies and 480,825 adults found nutritional deficiencies were common among GLP-1 users vitamin D, iron, calcium, and protein intake were among the recurring concerns, with vitamin D deficiency reported in 13.6% of users at 12 months
Clinical practice statement: protein intake recommendations during pharmacologic weight loss
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Strategies to mitigate this include gradual dose tapering rather than abrupt cessation, concurrent development of sustainable dietary and exercise habits, and potentially transitioning to lower maintenance doses rather than complete withdrawal
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