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Average weight loss with CagriSema hit 20.4%, and 22.7% when adjusted for full treatment adherence

A prolonged, untreated deficiency can cause nerve damage that may become permanent

This is particularly relevant with retatrutide, where the pace of weight loss is faster and the risk of excessive lean mass loss is proportionally higher, though the glucagon component may offer some muscle-sparing benefit

The lack of standardized experimental models and the complexity of bacterial metabolic networks further complicate the interpretation of results