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According to NICE NG28, GLP-1 receptor agonist treatment should only be continued if there is beneficial metabolic response (HbA1c reduction of at least 11 mmol/mol [1.0%] and weight loss of at least 3% of initial body weight at 6 months)

It must be taken on an empty stomach with no more than 4 ounces of plain water, at least 30 minutes before your first food, drink, or other oral medications

In some individuals, particularly early in treatment, there are reports of transient mild elevations in liver enzymes

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