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Mechanism of Action of GLP-1RAs in Type 2 Diabetes These effects have positioned GLP-1RAs as a cornerstone in the management of type 2 diabetes, particularly in individuals with obesity
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Use caution when initiating or escalating doses of Saxenda in patients with renal impairment
Structure-activity relationship: The Aib (alpha-aminoisobutyric acid) residue at position 1 confers resistance to aminopeptidase degradation, improving metabolic stability relative to natural ghrelin
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