Mechanisms of Action of GLP-1RAs: Beyond Glycaemic Control Endogenous glucagon-like peptide-1 (GLP-1) is a peptide hormone secreted by intestinal L cells and brainstem neurons in response to nutrient intake
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Over time, insulin resistance contributes to the development of obesity, diabetes and cardiovascular diseases, and sustained hyperinsulinemia contributes to the generation and/or maintenance of ovulatory dysfunction (175, 176)