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IGF-1 LR3 has been used extensively in this context precisely because its extended half-life allows sustained receptor activation in cell culture and in vivo models without the impractical dosing frequency that native IGF-1 would require
doi:10.1016/j.pneurobio.2005.04.003
doi: 10.1186/s12916-022-02477-z
The cycle planning guide discusses how to structure protocols for different goals
BMC Bioinform 9:465
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