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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
L-arginine synthesized in the liver does not reach the systemic circulation effectively because of the high activity of hepatic arginase 122,123
Consequently, disruptions in GSH biosynthesis, utilization, or recycling are hallmarks of oxidative stress and have been implicated in the pathogenesis of aging, neurodegenerative diseases like Parkinsons and Alzheimers, cancer, and various metabolic disorders [37]
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