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201 In breast cancer, elevated HSP90 levels stabilize estrogen receptor (ErbB)-dependent PI3K/AKT and ERK signaling pathways, counteracting the effects of hormonal therapies such as fulvestrant
Conversely, inhibition of the PI3K/AKT/mTOR signaling axis sensitizes cancer cells to ferroptosis induction (111)
In the pineal gland, serotonin undergoes enzymatic transformation into melatonin
The kinetics of the contents of the blood compartment are complicated because GSH and its component amino acids in the blood interact with the kidney, the brain, and other tissues
The potential association between SHBG and neurodegenerative diseases has been investigated in several studies employing Mendelian randomization methods to explore the impact of genetically predicted sex hormone levels on disease risk
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