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In the SURMOUNT-1 trial, the highest dose achieved approximately 22.5% weight loss over 72 weeks

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Factors That Influence How Long GLP-1 Stays in Your System While the drugs half-life gives a general idea, several individual factors can influence how long GLP-1 stays in your system: Metabolism: People with faster metabolic rates may break down GLP-1 faster

Ensure that you have as many of these throughout the day so that you are on the healthy side

This usually resolves as the body adjusts to GLP-1-only activation