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Lys240 is positioned close to Glu235 (~2.0 ), which together with Asn240 stabilizes a conserved water molecule

Thermodynamic analysis of the binding of glutathione to glutathione S-transferase over [PMID: 11488926] Laboratory literature summary: Thermodynamic analysis of the binding of glutathione to glutathione S-transferase over a range of temperatures

Rather, they fail within a complex, multicellular environment in which astrocytes, microglia, oligodendrocytes, vascular elements, and systemic immune components actively participate

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