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SSRIs and SNRIs (sertraline, escitalopram, duloxetine)
Jia L, Liao M, Mou A, Zheng Q, Yang W, Yu Z, et al
Some studies found that it could increase HDL (good) cholesterol while lowering LDL (bad) cholesterol
Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists
Clinical studies have shown remarkable outcomes, positioning retatrutide as a superior peptide for obesity and weight management research
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