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Glucose and amino acids cannot diffuse passively into the brain because of their polarity, so they are usually transported by carrier-mediated transcytosis
Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage
Accessed October 10, 2016
PMID 5642099
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