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The right choice depends on deficiency cause, route preference, tolerability, availability, and monitoring needs

[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered

Long-term storage at -20C is recommended to maintain maximum purity

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