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Protocol 2: tirzepatide microdose for autoimmune inflammation Goal: Leverage dual GIP/GLP-1 receptor activation for broader anti-inflammatory coverage Starting dose: 0.5 mg tirzepatide subcutaneously, once weekly Week 1 to 6: Hold at 0.5 mg

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M., Shong, Y

The lanes labeled 1, 2, and 3 correspond to LMNG/CHS solubilized fraction, anti-FLAG column flow-through, and purified complex, respectively for both ( c ) and ( d )

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Karagiannis T, Liakos A, Bekiari E et al (2015) Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonists for the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials