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Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M

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However, melatonin has also been shown to upregulate NMDA receptor subunits 2A and 2B in a dose-dependent manner in the rat hippocampus [80]

NHPN-1010 induced the attenuation of tinnitus as evidenced by behavioral measures To test for tinnitus, the basic hypothesis is twofold: (1) a reduction in the amplitude of the startle response when it is preceded by a brief gap in a background sound indicates that gap can reduce the normal startle response to a loud sound, and (2) the startle stimulus is preceded by the perceived gap with the idea that an animals tinnitus will make the gap less salient and therefore less effective in reducing the startle response