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In this regard, a model of human tumor metastasis may prove a valuable approach for the evaluation of penetration potential, enhanced permeability, and retention of nanoparticles, and also for targeting the metastatic tissues compared to primary tissues

A number of studies have indicated that, as compared with mammals, the responses of the activities of many glucose metabolism-related key enzymes, such as GK, PFK and PK, are not sensitive to the increased dietary carbohydrate content in fish 36,37

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