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[57] Preclinical studies suggest semaglutide counteracts these processes by activating the AMPK and SIRT1 pathways, which are fundamental for cellular autophagy and mitophagy

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Patients with diabetes who are initiating GLP-1 RAsespecially those with elevated baseline hemoglobin A1c or anticipated rapid reductionmay benefit from being monitored more closely than suggested by the American Academy of Ophthalmology preferred practice pattern, which is based on the current level of retinopathy

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