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Theoretical concerns about telomerase activation Because epitalon influences telomerase activity and gene expression, theoretical concerns exist about potential unintended consequences such as abnormal cell proliferation
The regulation of NSC proliferation, self-renewal, and differentiation is finely regulated by changes in the surrounding microenvironment, or niche, in which NSCs reside (reviewed in Hepatocyte growth factor contributes to the maintenance of self-renewal and proliferation of NSCs in SVZ, which express MET and produce HGF
Adjacent compounds include metallopeptides, peptide analogs, and synthetic peptides used in molecular biology, biochemistry, and pharmacological research frameworks
Historical View: Early researchers described DSIP as incredibly safe. Animal studies failed to identify a lethal dose (LD50), and human trials reported no significant adverse events other than transient headaches or nausea