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*Correspondence: Xian-Feng Zhang, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Signs your dose needs adjustment Increase dose consideration: Minimal response after 3-4 weeks at current dose, stable weight and measurements despite consistent protocol adherence, absence of any subjective improvements in energy or fasted tolerance

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It facilitates muscle glucose uptake and also exerts systemic effects