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Cardiovascular outcomes, long-term efficacy and safety In people with T2D and established cardiovascular disease, the international guidelines for T2D recommend the use of GLP-1 RA or sodium glucose co-transporters 2 inhibitors (SGLT-2i) as first-line treatment (independent of HbA1c), based on multiple trials demonstrating their cardio-renal benefits [109]

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KD is a high-fat, very low-carbohydrate, and moderate-protein dietary approach that induces ketosis, defined by serum ketone body concentrations exceeding 0.5 mmol/L

The cell receives protection at multiple points in the death pathway, from the initial decision to the final execution