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Nevertheless, although bariatric surgery appears to provide clinical benefits, such as significant reductions in the number of anatomical sites involved and overall disease activity, some reports have also described disease worsening after this intervention, possibly related to nutritional deficiencies or increased friction in skin folds secondary to rapid weight loss.2,811 In this context, GLP-1 receptor agonists (GLP-1 RAs), such as liraglutide and semaglutide, have demonstrated not only beneficial effects on weight reduction and other metabolic parameters, but also a capacity to lower the risk of cardiovascular events independently of weight loss, potentially through anti-inflammatory mechanisms

Figure 1 Several studies have shown that oncogenic and anti-oncogenic alterations in cancer cells may reprogram glutamine metabolism

Liposomal NAD+: A cellular coenzyme that plays a key role in mitochondrial energy production, metabolic health, and healthy aging pathways