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Introduction It is serendipitous (or perhaps indicative of hard work) that the Nobel prize winner Szent-Gyorgyi discovered both ascorbic acid (vitamin C) and the flavonoid quercetin (at the time labeled vitamin P) (1)
ROC analyses were completed to identify cut-points for severity thresholds between anchor categories, including a) the whole population (e.g., No to Moderate versus Severe) or b) only individuals in adjacent categories (e.g., Moderate versus Severe) to estimate the threshold, first at all timepoints in a stacked dataset and then split by timepoint (Baseline/Post-Baseline)
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