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for review, see Sikiric et al., 2018) persists against the notion of continuous, direct injury (increased intra-abdominal hypertension) and shows that organs may adequately function despite continuously elevated intra-abdominal pressure
The therapeutic utility of native GLP-1 is limited by its rapid degradation [2], primarily mediated by dipeptidyl peptidase-4 (DPP-4) and secondarily by neutral endopeptidases (NEPs) and renal clearance [3, 4]
It is not known if tirzepatide will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in humans
Endocrinology 149 (8), 40594068
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