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Currently, a major gap in the field that applies here relates to the need for a diagnostic biomarker in humans that correlates with pre-neoplastic disease progression (e.g., indicating a high grade PanIN)
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Importantly, clinical evidence in humans remains extremely limited, meaning that promising animal results should be interpreted cautiously until validated in well-controlled trials
The FDA could approve orforglipron and oral semaglutide by 2026
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