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The studies summarized below are predominantly preclinical and should be interpreted accordingly

9.1 Comparative mechanisms of action At the level of monoaminergic modulation, Rhodiola rosea demonstrates the most direct enhancement of serotonergic, dopaminergic, and noradrenergic neurotransmission, mediated in part through monoamine oxidase inhibition and presynaptic modulation of neurotransmitter availability (99)

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Our work is the first study demonstrating the role of Sirt1/Foxo-1 in regulating the regulatory function of a GLP-1 receptor agonist in adiponectin expression both in vitro and in vivo

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