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Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress
It is approved for weight management in adults and pediatric patients 12 years and older with obesity, as well as adults with overweight who have at least one weight-related health condition
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However, uncontrolled trans-cleavage poses risks of off-target genomic damage, requiring careful optimization of delivery systems to restrict activity to tumor cells
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