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Three, B12 supplementation is used, and the optimal frequency of administration is established in order to stay symptom-free

In vivo , ICA treatment partially restored type II collagen and GPX4 expression, reduced ECM degradation in chondrocytes, and restrained chondrocyte ferroptosis, alleviating OA joint damage

it addresses both the cellular trigger (oxidative stress in the mast cell) and the systemic clearance mechanism (hepatic detoxification)

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