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Several hub genes of PANoptosis, such as CASP1, YWHAH, and TAP1, are significantly upregulated during DKD progression, correlating with glomerular filtration rate decline and clinical severity (209, 212)

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CagriSema demonstrated superior HbA1c reduction of 1.91 points and weight loss of 14.2% in adults with type 2 diabetes in the REIMAGINE 2 trial

4.2 Environmental and health implications The environmental presence of antibiotics contributes to the propagation of antimicrobial resistance (AMR), recognized as a global public health emergency [105]

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