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Comparisons between different trials should be interpreted cautiously because study populations and designs differ
2018;2018(3):rjy040
This typically begins after the weight-loss nadir, around 1224 months post-operatively, though timing can vary considerably
Consistent with a direct anti-inflammatory effect in multiple cell types, FGF21 inhibits macrophage expression of the pro-inflammatory cytokines TNF, IL-6, IL-1, and IFN- by inducing NRF2 nuclear translocation, thereby blocking NF-B activation (177)
Complete loss of appetite, making daily protein intake goals (often around 1 gram per pound of body weight) feel impossible
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