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PMCID: PMC8703152
By signaling through GLP-1R expressed in the reward and satiety areas of central nervous system, GLP-1RAs reduce caloric intake and result in 14 kg weight loss on average over several months
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Both hexarelin and ipamorelin are synthetic growth hormone secretagogues (GHS) that act as agonists at the ghrelin receptor, formally GHSR-1a (growth hormone secretagogue receptor type 1a)
The paper explores the science at the intersection of metabolic hormones and precision nutrition and multi-target therapies, like tirzepatide and retatrutide.
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