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Many patients experience modest weight rebound (2 to 5 pounds) during a 2 to 4 week medication pause, though individual responses vary

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Intracellular depletion of cAMP and cGMP following their hydrolysis by phosphodiesterase (PDE) enzymes augments inflammatory responses

Neurological Fatigue: By reducing elevated ventricular lactate and supporting efficient mitochondrial ATP production in the brain, NAC helps alleviate the heavy, "weighted" feeling in the head often reported by patients

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