Citing limitations in the study, Novo Nordisk, which makes the drugs included in the claims analysis, said in a statement reported by Reuters that it does not believe these data are sufficient to draw conclusions about overall patient adherence and persistence to various GLP-1 medicines, including our treatments. Nonetheless, the problem of lack of patient persistence on GLP-1s under real-world conditions, examined and published by a growing number of sources, isnt going away
Temporarily putting aside the desire for head-to-head RCTs, systematic reviews of clinical trial data (both Phase 3 registration trials and smaller studies), describe FFM loss relative to total weight loss
STEP-1 (semaglutide 2.4 mg) and medication use In STEP-1 (N=1,961), semaglutide 2.4 mg produced 14.9% mean weight loss at 68 weeks vs
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Strengths and limitations This study possesses several methodological strengths