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Downregulation of Endogenous Peptide Production Introducing exogenous peptides may signal the body to decrease its own production of these compounds (a concept well-understood with hormonal therapies)

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Moreover, HIF-1 plays a central role in regulating immune evasion, glycolysis, metastasis, and tumor progression, particularly in triple-negative breast cancer (TNBC), highlighting its broad impact on tumor biology [162]